Cancer is one of the leading causes of death worldwide and its incidence is expected to increase in the future. The conduction of cancer clinical trials in Brazil and Latin American countries is increasing. Some key countries have plenty of conditions to participate more often in clinical trials which are primarily conducted in developed countries. Cancer network organizations are joining efforts to partner with pharmaceutical/biotechnology industries and public institutions looking for funding opportunities and to expose the region for more active participation in multicenter clinical trials. Regulatory agencies are demonstrating willingness to expedite approvals. Many positive aspects attract the conduction of clinical trials in Brazil and Latin American countries, recruitment, western medicine, excellent oncology centers from public and private sectors, cost-effectiveness and reliable data. Opportunities and challenges while conducting cancer clinical trials in Brazil and Latin American countries will be discussed in this session.